View source for 5cwu


==Crystal structure of Chaetomium thermophilum Nup188 TAIL domain==
<StructureSection load='5cwu' size='340' side='right'caption='[[5cwu]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cwu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CWU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cwu OCA], [https://pdbe.org/5cwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cwu RCSB], [https://www.ebi.ac.uk/pdbsum/5cwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cwu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NU188_CHATD NU188_CHATD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kDa inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1*Nup49*Nup57 channel nucleoporin hetero-trimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT*Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. We propose that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation.

Architecture of the fungal nuclear pore inner ring complex.,Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A Science. 2015 Aug 27. pii: aac9176. PMID:26316600<ref>PMID:26316600</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5cwu" style="background-color:#fffaf0;"></div>

==See Also==
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Bley CJ]]
[[Category: Collins LN]]
[[Category: Fischer J]]
[[Category: Hoelz A]]
[[Category: Hurt E]]
[[Category: Jeon YE]]
[[Category: Koide A]]
[[Category: Koide S]]
[[Category: Kossiakoff AA]]
[[Category: Lin DH]]
[[Category: Lu V]]
[[Category: Mayo DJ]]
[[Category: Paduch M]]
[[Category: Perriches T]]
[[Category: Petrovic S]]
[[Category: Rundlet EJ]]
[[Category: Schilbach S]]
[[Category: Stuwe T]]
[[Category: Thierbach K]]