View source for 5cyo


==High resolution Septin 9 GTPase domain in complex with GDP==
<StructureSection load='5cyo' size='340' side='right'caption='[[5cyo]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CYO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0354&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyo OCA], [https://pdbe.org/5cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cyo RCSB], [https://www.ebi.ac.uk/pdbsum/5cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref>   The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Araujo APU]]
[[Category: Garratt RC]]
[[Category: Horjales E]]
[[Category: Leonardo DA]]
[[Category: Matos SS]]
[[Category: Pereira HM]]