View source for 5czr


==Crystal Structure of Human Protocadherin-24 EC1-2==
<StructureSection load='5czr' size='340' side='right'caption='[[5czr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5czr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CZR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5czr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czr OCA], [https://pdbe.org/5czr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5czr RCSB], [https://www.ebi.ac.uk/pdbsum/5czr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5czr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDHR2_HUMAN CDHR2_HUMAN] Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).<ref>PMID:12117771</ref> <ref>PMID:24725409</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Johnson ZR]]
[[Category: Sotomayor M]]