View source for 5dcw


==Iridoid synthase from Catharanthus roseus - ligand free structure==
<StructureSection load='5dcw' size='340' side='right'caption='[[5dcw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dcw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DCW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcw OCA], [https://pdbe.org/5dcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dcw RCSB], [https://www.ebi.ac.uk/pdbsum/5dcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dcw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRIS_CATRO IRIS_CATRO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted.

Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396<ref>PMID:26551396</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5dcw" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Catharanthus roseus]]
[[Category: Large Structures]]
[[Category: Caputi L]]
[[Category: Geu-Flores F]]
[[Category: Kamileen MO]]
[[Category: Kries H]]
[[Category: Lawson DM]]
[[Category: O'Connor SE]]
[[Category: Sherden NH]]
[[Category: Stevenson CEM]]