View source for 5dkg


==Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a t-butyl-substituted, methyl, triaryl-ethylene derivative 4,4'-[2-(4-tert-butylphenyl)prop-1-ene-1,1-diyl]diphenol==
<StructureSection load='5dkg' size='340' side='right'caption='[[5dkg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dkg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5C7:4,4-[2-(4-TERT-BUTYLPHENYL)PROP-1-ENE-1,1-DIYL]DIPHENOL'>5C7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkg OCA], [https://pdbe.org/5dkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkg RCSB], [https://www.ebi.ac.uk/pdbsum/5dkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
== Function ==
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref> 

==See Also==
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Carlson KE]]
[[Category: Cavett V]]
[[Category: Dong C]]
[[Category: Elemento O]]
[[Category: Houtman R]]
[[Category: Josan JS]]
[[Category: Katzenellenbogen JA]]
[[Category: Liao Z]]
[[Category: Min J]]
[[Category: Nettles KW]]
[[Category: Nowak J]]
[[Category: Nwachukwu JC]]
[[Category: Srinivasan S]]
[[Category: Wang S]]
[[Category: Zheng Y]]
[[Category: Zhou HB]]