View source for 5doe


==Crystal structure of the Human Cytomegalovirus UL53 (residues 72-292)==
<StructureSection load='5doe' size='340' side='right'caption='[[5doe]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5doe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DOE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5doe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doe OCA], [https://pdbe.org/5doe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5doe RCSB], [https://www.ebi.ac.uk/pdbsum/5doe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5doe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEC1_HCMVA NEC1_HCMVA] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04023]<ref>PMID:25339763</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human herpesvirus 5 strain AD169]]
[[Category: Large Structures]]
[[Category: El Omari K]]
[[Category: Filman DJ]]
[[Category: Hogle JM]]
[[Category: Lye MF]]