View source for 5dwy


==Crystal structure of a substrate-free glutamate transporter homologue GltTk==
<StructureSection load='5dwy' size='340' side='right'caption='[[5dwy]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dwy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DWY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dwy OCA], [https://pdbe.org/5dwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dwy RCSB], [https://www.ebi.ac.uk/pdbsum/5dwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dwy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5JID0_THEKO Q5JID0_THEKO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Glutamate transporters catalyse the thermodynamically unfavourable transport of anionic amino acids across the cell membrane by coupling it to the downhill transport of cations. This coupling mechanism is still poorly understood, in part because the available crystal structures of these transporters are of relatively low resolution. Here we solve crystal structures of the archaeal transporter GltTk in the presence and absence of aspartate and use molecular dynamics simulations and binding assays to show how strict coupling between the binding of three sodium ions and aspartate takes place.

Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk.,Guskov A, Jensen S, Faustino I, Marrink SJ, Slotboom DJ Nat Commun. 2016 Nov 10;7:13420. doi: 10.1038/ncomms13420. PMID:27830699<ref>PMID:27830699</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5dwy" style="background-color:#fffaf0;"></div>

==See Also==
*[[Symporter 3D structures|Symporter 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Guskov A]]
[[Category: Slotboom DJ]]