View source for 5dxy


==Crystal structure of Dbr2==
<StructureSection load='5dxy' size='340' side='right'caption='[[5dxy]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_annua Artemisia annua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DXY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J8:[[(2R,3S,4R,5R)-5-(5-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl+hydrogen+phosphate'>5J8</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dxy OCA], [https://pdbe.org/5dxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dxy RCSB], [https://www.ebi.ac.uk/pdbsum/5dxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dxy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DBR2_ARTAN DBR2_ARTAN] Involved in the biosynthesis of the antimalarial endoperoxide artemisinin by catalyzing the double bond reduction of (11R)-dihydroartemisinic aldehyde to produce artemisinic aldehyde. Also able to reduce artemisinic alcohol and artemisinic acid to a lesser extent.<ref>PMID:18495659</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Artemisia annua]]
[[Category: Large Structures]]
[[Category: Chen TT]]
[[Category: Li L]]
[[Category: Xu YC]]