View source for 5eai


==Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a==
<StructureSection load='5eai' size='340' side='right'caption='[[5eai]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eai]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E6A:(2~{R},3~{R})-2-[(2~{S},3~{S})-3-BROMANYL-1,4-BIS(OXIDANYLIDENE)-2,3-DIHYDRONAPHTHALEN-2-YL]-3-OXIDANYL-2,3-DIHYDRONAPHTHALENE-1,4-DIONE'>E6A</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eai OCA], [https://pdbe.org/5eai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eai RCSB], [https://www.ebi.ac.uk/pdbsum/5eai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eai ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ahmad M]]
[[Category: Emadi A]]
[[Category: Mbimba JE]]
[[Category: Pidugu LS]]
[[Category: Pozharski E]]
[[Category: Sausville EA]]
[[Category: Toth EA]]