View source for 5ec4


==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 13g and CoA==
<StructureSection load='5ec4' size='340' side='right'caption='[[5ec4]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ec4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EC4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5LQ:5-(3-CHLOROPHENYL)-4-METHYL-~{N}-(3-MORPHOLIN-4-YLPROPYL)-1,1-BIS(OXIDANYLIDENE)-1,2-THIAZOL-3-AMINE'>5LQ</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ec4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ec4 OCA], [https://pdbe.org/5ec4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ec4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ec4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ec4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EIS_MYCTU EIS_MYCTU] May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.<ref>PMID:10629183</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Gajadeera CS]]
[[Category: Garneau-Tsodikova S]]
[[Category: Hou C]]
[[Category: Tsodikov OV]]