View source for 5ed8


==Crystal structure of CC2-SUN of mouse SUN2==
<StructureSection load='5ed8' size='340' side='right'caption='[[5ed8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ed8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ED8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ED8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ed8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ed8 OCA], [https://pdbe.org/5ed8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ed8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ed8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ed8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUN2_MOUSE SUN2_MOUSE] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.<ref>PMID:16380439</ref> <ref>PMID:19509342</ref> <ref>PMID:19843581</ref> <ref>PMID:19874786</ref> <ref>PMID:20724637</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Feng W]]
[[Category: Gao F]]
[[Category: Gong WM]]
[[Category: Huo L]]
[[Category: Ke HM]]
[[Category: Nie S]]
[[Category: Ren JQ]]
[[Category: Wang MZ]]