View source for 5efs


==The crystal structure of human kynurenine aminotransferase II==
<StructureSection load='5efs' size='340' side='right'caption='[[5efs]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5efs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EFS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82503&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5efs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5efs OCA], [https://pdbe.org/5efs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5efs RCSB], [https://www.ebi.ac.uk/pdbsum/5efs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5efs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> 

==See Also==
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Church WB]]
[[Category: Hanrahan JR]]
[[Category: Harrop SJ]]
[[Category: Kwan A]]
[[Category: Nadvi NA]]
[[Category: Nematollahi A]]
[[Category: Sun G]]