View source for 5egi


==Structure of a Trimeric Intracellular Cation channel from C. elegans with bound Ca2+==
<StructureSection load='5egi' size='340' side='right'caption='[[5egi]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5egi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=PT5:(1S)-2-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(8E,11E)-ICOSA-5,8,11,14-TETRAENOATE'>PT5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5egi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egi OCA], [https://pdbe.org/5egi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5egi RCSB], [https://www.ebi.ac.uk/pdbsum/5egi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5egi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/T38B1_CAEEL T38B1_CAEEL] Potassium channel that mediates transmembrane potassium transport (PubMed:27698420). Might be required for maintenance of rapid intracellular calcium release (By similarity). May act as a counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27698420).[UniProtKB:Q9DAV9]<ref>PMID:27698420</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Hu MH]]
[[Category: Liu ZF]]
[[Category: Yang HT]]