View source for 5elh


==Crystal structure of mouse Unkempt zinc fingers 1-3 (ZnF1-3), bound to RNA==
<StructureSection load='5elh' size='340' side='right'caption='[[5elh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5elh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ELH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5elh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elh OCA], [https://pdbe.org/5elh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5elh RCSB], [https://www.ebi.ac.uk/pdbsum/5elh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5elh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UNK_MOUSE UNK_MOUSE] Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).<ref>PMID:25737280</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Murn J]]
[[Category: Patel DJ]]
[[Category: Shi Y]]
[[Category: Teplova M]]
[[Category: Zarnack K]]