View source for 5evg


==Crystal structure of a Francisella virulence factor FvfA in the orthorhombic form==
<StructureSection load='5evg' size='340' side='right'caption='[[5evg]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5evg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._novicida Francisella tularensis subsp. novicida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EVG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5evg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evg OCA], [https://pdbe.org/5evg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5evg RCSB], [https://www.ebi.ac.uk/pdbsum/5evg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5evg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0Q625_FRATN A0Q625_FRATN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Francisella tularensis is a potent human pathogen that invades and survives in macrophage and epithelial cells. Two identical proteins, FTT_0924 from F. tularensis subsp. tularensis and FTL_1286 from F. tularensis subsp. holarctica LVS, have previously been identified as playing a role in protection of the bacteria from osmotic shock and its survival in macrophages. FTT_0924 has been shown to localize to the inner membrane, with its C-terminus exposed to the periplasm. Here, crystal structures of the F. novicida homologue FTN_0802, which we call FvfA, in two crystal forms are reported at 1.8 A resolution. FvfA differs from FTT_0924 and FTL_1286 by a single amino acid. FvfA has a DUF1471 fold that closely resembles the Escherichia coli outer membrane lipoprotein RscF, a component of a phosphorelay pathway involved in protecting bacteria from outer membrane perturbation. The structural and functional similarities and differences between these proteins and their implications for F. tularensis pathogenesis are discussed.

Structure of the conserved Francisella virulence protein FvfA.,Kolappan S, Lo KY, Shen CLJ, Guttman JA, Craig L Acta Crystallogr D Struct Biol. 2017 Oct 1;73(Pt 10):814-821. doi:, 10.1107/S205979831701333X. Epub 2017 Sep 27. PMID:28994410<ref>PMID:28994410</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5evg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Francisella tularensis subsp. novicida]]
[[Category: Large Structures]]
[[Category: Craig L]]
[[Category: Guttman JA]]
[[Category: Kolappan S]]
[[Category: Lo KY]]
[[Category: Shen CLJ]]