View source for 5ewv


==Crystal structure of the human BRPF1 bromodomain in complex with SEED20==
<StructureSection load='5ewv' size='340' side='right'caption='[[5ewv]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ewv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EWV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5SN:1,5-DIMETHYL-[1,2,4]TRIAZOLO[4,3-A]QUINOLINE'>5SN</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ewv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewv OCA], [https://pdbe.org/5ewv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ewv RCSB], [https://www.ebi.ac.uk/pdbsum/5ewv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ewv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 

==See Also==
*[[Peregrin|Peregrin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Caflisch A]]
[[Category: Wiedmer L]]
[[Category: Zhu J]]