View source for 5eyz


==CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE TAILORED PEPTIDE CYTO8-RETEV==
<StructureSection load='5eyz' size='340' side='right'caption='[[5eyz]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eyz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EYZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eyz OCA], [https://pdbe.org/5eyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eyz RCSB], [https://www.ebi.ac.uk/pdbsum/5eyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eyz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN] May act at junctions between the membrane and the cytoskeleton.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The human protein tyrosine phosphatase non-receptor type 4 (PTPN4) prevents cell death induction in neuroblastoma and glioblastoma cell lines in a PDZ-PDZ binding motifs (PBMs) dependent manner but the cellular partners of PTPN4 involved in cell protection are unknown. Here, we described the Mitogen-Activated protein kinase p38gamma as a cellular partner of PTPN4. The main contribution to the p38gamma:PTPN4 complex formation is the tight interaction between the C-terminus of p38gamma and the PDZ domain of PTPN4. We solved the crystal structure of the PDZ domain of PTPN4 bound to the p38gamma C-terminus. We identified the molecular basis of recognition of the C-terminal sequence of p38gamma that displays the highest affinity amongst all endogenous partners of PTPN4. We showed that the p38gamma C-terminus is also an efficient inducer of cell death after its intracellular delivery. In addition to recruiting the kinase, the binding of the C-terminal sequence of p38gamma to PTPN4 abolishes the catalytic auto-inhibition of PTPN4 and thus activates the phosphatase that can efficiently dephosphorylate the activation loop of p38gamma. We presume that the p38gamma-PTPN4 interaction promotes cellular signaling preventing cell death induction.

Molecular Basis of The Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-Activated Protein Kinase p38gamma.,Maisonneuve P, Caillet-Saguy C, Vaney MC, Edoo BZ, Sawyer K, Raynal B, Delepierre M, Lafon M, Cordier F, Wolff N J Biol Chem. 2016 May 31. pii: jbc.M115.707208. PMID:27246854<ref>PMID:27246854</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5eyz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Babault B]]
[[Category: Caillet-Saguy C]]
[[Category: Cordier F]]
[[Category: Delepierre M]]
[[Category: Lafon M]]
[[Category: Maisonneuve P]]
[[Category: Vaney MC]]
[[Category: Wolff N]]