View source for 5ffw


==Crystal structure of the bromodomain of human BRPF1 in complex with H4K5acK8ac histone peptide==
<StructureSection load='5ffw' size='340' side='right'caption='[[5ffw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ffw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FFW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ffw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ffw OCA], [https://pdbe.org/5ffw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ffw RCSB], [https://www.ebi.ac.uk/pdbsum/5ffw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ffw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 

==See Also==
*[[Peregrin|Peregrin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Knapp S]]
[[Category: Krojer T]]
[[Category: Nunez-Alonso G]]
[[Category: Savitsky P]]
[[Category: Tallant C]]
[[Category: Von Delft F]]