View source for 5fwz


==Fasciola hepatica calcium binding protein FhCaBP2: Structure of the dynein light chain-like domain. P41212 mercury derivative.==
<StructureSection load='5fwz' size='340' side='right'caption='[[5fwz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5fwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FWZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwz OCA], [https://pdbe.org/5fwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fwz RCSB], [https://www.ebi.ac.uk/pdbsum/5fwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fwz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0B5GUS3_FASHE A0A0B5GUS3_FASHE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain). The function of these proteins is unknown, although in several species, they have been localised to the tegument, an important structure at the host-parasite interface. Here, we report the X-ray crystal structure of the DLC-like domain of F. hepatica calcium-binding protein 2 (FhCaBP2), solved using single-wavelength anomalous diffraction and refined at 2.3 A resolution in two different crystal forms. The FhCaBP2 DLC-like domain has a structure similar to other DLC domains, with an anti-parallel beta-sheet packed against an alpha-helical hairpin. Like other DLC domains, it dimerises through its beta2-strand, which extends in an arch and forms the fifth strand in an extended beta-sheet of the other monomer. The structure provides molecular details of the dimerisation of FhCaBP2, the first example from this family of parasite proteins.

Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain.,Nguyen TH, Thomas CM, Timson DJ, van Raaij MJ Parasitol Res. 2016 Apr 16. PMID:27083189<ref>PMID:27083189</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5fwz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fasciola hepatica]]
[[Category: Large Structures]]
[[Category: Nguyen TH]]
[[Category: Thomas CM]]
[[Category: Timson DJ]]
[[Category: Van Raaij MJ]]