View source for 5gph


==Solution structure of the Pin1-PPIase (S138A) mutant==
<StructureSection load='5gph' size='340' side='right'caption='[[5gph]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5gph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gph OCA], [https://pdbe.org/5gph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gph RCSB], [https://www.ebi.ac.uk/pdbsum/5gph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gph ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> 

==See Also==
*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Tate S]]
[[Category: Tochio N]]
[[Category: Wang J]]