View source for 5gpq


==Crystal Structure of zebrafish ASC CARD Domain==
<StructureSection load='5gpq' size='340' side='right'caption='[[5gpq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5gpq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpq OCA], [https://pdbe.org/5gpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpq RCSB], [https://www.ebi.ac.uk/pdbsum/5gpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASC_DANRE ASC_DANRE] Functions as key mediator in apoptosis and inflammation (PubMed:12464617, PubMed:30150286). Promotes caspase-mediated apoptosis (PubMed:12464617). Induces proteolytic processing of caspa and caspa-dependent apoptosis (PubMed:12464617). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:30150286). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (PubMed:30150286). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity).[UniProtKB:Q9ULZ3]<ref>PMID:12464617</ref> <ref>PMID:30150286</ref> [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
== References ==
<references/>
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Jin T]]
[[Category: Li Y]]