View source for 5gvt


==Crystal structures of the serine protease domain of murine plasma kallikrein==
<StructureSection load='5gvt' size='340' side='right'caption='[[5gvt]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5gvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GVT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gvt OCA], [https://pdbe.org/5gvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gvt RCSB], [https://www.ebi.ac.uk/pdbsum/5gvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gvt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KLKB1_MOUSE KLKB1_MOUSE] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

==See Also==
*[[Kallikrein 3D structures|Kallikrein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Huang M]]
[[Category: Jiang L]]
[[Category: Xu M]]