View source for 5hba


==Globular Domain of Zebrafish Complement 1qA protein==
<StructureSection load='5hba' size='340' side='right'caption='[[5hba]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hba]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HBA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hba OCA], [https://pdbe.org/5hba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hba RCSB], [https://www.ebi.ac.uk/pdbsum/5hba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hba ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F1QFM5_DANRE F1QFM5_DANRE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
C1q contains three globular domains (C1qgD) that are the key functional component of the classical complement system. C1qgD can interact with important immune molecules, including IgG and C-reactive protein (CRP) to form defense systems to protect animals. Here, the first non-mammalian structure, zebrafish C1qA globular domain (Dare-C1qAgD) was solved. Although the overall architecture of Dare-C1qAgD is similar to human C1qA, residues involved in C1qBgD, C1qCgD, and CRP binding are somewhat different while residues involved in IgG binding are not present in zebrafish. The structure gives insight into how human and fish C1qA evolved from an ancestral protein.

Crystal structure of zebrafish complement 1qA globular domain.,Yuan H, Chen R, Tariq M, Liu Y, Sun Y, Xia C Protein Sci. 2016 Oct;25(10):1883-9. doi: 10.1002/pro.2980. Epub 2016 Sep 13. PMID:27391278<ref>PMID:27391278</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5hba" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Chen R]]
[[Category: Xia C]]
[[Category: Yuan H]]