View source for 5hdt


==Human cohesin regulator Pds5B bound to a Wapl peptide==
<StructureSection load='5hdt' size='340' side='right'caption='[[5hdt]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hdt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HDT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.711&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hdt OCA], [https://pdbe.org/5hdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hdt RCSB], [https://www.ebi.ac.uk/pdbsum/5hdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hdt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDS5B_HUMAN PDS5B_HUMAN] Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.<ref>PMID:10963680</ref> <ref>PMID:15855230</ref> <ref>PMID:19696148</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ouyang Z]]
[[Category: Tomchick DR]]
[[Category: Yu H]]