View source for 5hnm


==Crystal structure of vancomycin resistance D,D-pentapeptidase VanY E175A mutant from VanB-type resistance cassette in complex with Zn(II)==
<StructureSection load='5hnm' size='340' side='right'caption='[[5hnm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hnm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HNM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnm OCA], [https://pdbe.org/5hnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hnm RCSB], [https://www.ebi.ac.uk/pdbsum/5hnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VANY_ENTFA VANY_ENTFA] Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams.

==See Also==
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
__TOC__
</StructureSection>
[[Category: Enterococcus faecalis V583]]
[[Category: Large Structures]]
[[Category: Anderson WF]]
[[Category: Chun J]]
[[Category: Courvalin P]]
[[Category: Di Leo R]]
[[Category: Evdokimova E]]
[[Category: Savchenko A]]
[[Category: Stogios PJ]]
[[Category: Wawrzak Z]]
[[Category: Yim V]]