View source for 5hrj


==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163==
<StructureSection load='5hrj' size='340' side='right'caption='[[5hrj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [https://pdbe.org/5hrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [https://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C163A_PIG C163A_PIG] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref>   After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Jiang L]]
[[Category: Li R]]
[[Category: Ma H]]
[[Category: Qiao S]]
[[Category: Zhang G]]