View source for 5ihj


==Fusion of Maltose-binding Protein and PilA from Acinetobacter baumannii BIDMC57==
<StructureSection load='5ihj' size='340' side='right'caption='[[5ihj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ihj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_sp._216872 Acinetobacter sp. 216872] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PRD_900009:alpha-maltotriose'>PRD_900009</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihj OCA], [https://pdbe.org/5ihj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ihj RCSB], [https://www.ebi.ac.uk/pdbsum/5ihj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections. A. baumannii expresses a variety of virulence factors, including type IV pili, a bacterial extracellular appendage often essential for attachment to host cells. Here, we report the high-resolution structures of the major pilin subunit, PilA, from three Acinetobacter strains, demonstrating that A. baumannii subsets produce morphologically distinct type IV pilin glycoproteins. We examine the consequences of this heterogeneity for protein folding and assembly as well as host-cell adhesion by Acinetobacter. Comparisons of genomic and structural data with pilin proteins from other species of soil gammaproteobacteria suggest that these structural differences stem from evolutionary pressure which has resulted in three distinct classes of type IVa pilins, each found in multiple species.

Structural diversity in the type IV pili of multidrug-resistant Acinetobacter.,Piepenbrink KJ, Lillehoj EP, Harding CM, Labonte JW, Zuo X, Rapp CA, Munson RS Jr, Goldblum SE, Feldman MF, Gray JJ, Sundberg EJ J Biol Chem. 2016 Sep 15. pii: jbc.M116.751099. PMID:27634041<ref>PMID:27634041</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ihj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acinetobacter sp. 216872]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Piepenbrink KH]]
[[Category: Sundberg EJ]]