View source for 5ipu


==Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6==
<SX load='5ipu' size='340' side='right' viewer='molstar' caption='[[5ipu]], [[Resolution|resolution]] 15.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ipu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IPU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ipu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipu OCA], [https://pdbe.org/5ipu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ipu RCSB], [https://www.ebi.ac.uk/pdbsum/5ipu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NMDZ1_XENLA NMDZ1_XENLA] Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref.11, PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).<ref>PMID:16214956</ref> <ref>PMID:19524674</ref> <ref>PMID:21677647</ref> <ref>PMID:25008524</ref> <ref>PMID:26912815</ref> <ref>PMID:27135925</ref> <ref>PMID:28232581</ref> [PDB:5IOV]

==See Also==
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Goehring A]]
[[Category: Gouaux E]]
[[Category: Lee CH]]
[[Category: Mchaourab SH]]
[[Category: Stein AR]]
[[Category: Yoshioka C]]
[[Category: Zhu S]]