View source for 5iqq


==Crystal structure of the human RBM7 RRM domain==
<StructureSection load='5iqq' size='340' side='right'caption='[[5iqq]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iqq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqq OCA], [https://pdbe.org/5iqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqq RCSB], [https://www.ebi.ac.uk/pdbsum/5iqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBM7_HUMAN RBM7_HUMAN] Possible involved in germ cell RNA processing and meiosis.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA decay is an important process that is essential for controlling the abundance, quality and maturation of transcripts. In eukaryotes, RNA decay in the 3'-5' direction is carried out by the exosome, an RNA-degradation machine that is conserved from yeast to humans. A range of cofactors stimulate the enzymatic activity of the exosome and serve as adapters for the many RNA substrates. In human cells, the exosome associates with the heterotrimeric nuclear exosome targeting (NEXT) complex consisting of the DExH-box helicase hMTR4, the zinc-finger protein hZCCHC8 and the RRM-type protein hRBM7. Here, the 2.5 A resolution crystal structure of the RRM domain of human RBM7 is reported. Molecular replacement using a previously determined solution structure of RBM7 was unsuccessful. Instead, RBM8 and CBP20 RRM-domain crystal structures were used to successfully determine the RBM7 structure by molecular replacement. The structure reveals a ring-shaped pentameric assembly, which is most likely a consequence of crystal packing.

RRM domain of human RBM7: purification, crystallization and structure determination.,Sofos N, Winkler MB, Brodersen DE Acta Crystallogr F Struct Biol Commun. 2016 May 1;72(Pt 5):397-402. doi:, 10.1107/S2053230X16006129. Epub 2016 Apr 22. PMID:27139832<ref>PMID:27139832</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5iqq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brodersen DE]]
[[Category: Sofos N]]
[[Category: Winkler MBL]]