View source for 5is1


==Crystal structure of the extracellular domain of sensor histidine kinase YycG from Staphylococcus aureus at 2.0 Angstrom resolution==
<StructureSection load='5is1' size='340' side='right'caption='[[5is1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5is1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IS1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5is1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is1 OCA], [https://pdbe.org/5is1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5is1 RCSB], [https://www.ebi.ac.uk/pdbsum/5is1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5is1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WALK_STAA8 WALK_STAA8] Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins (PubMed:14762013, PubMed:17827301, PubMed:22825451). Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression (PubMed:14762013, PubMed:22825451).<ref>PMID:14762013</ref> <ref>PMID:17827301</ref> <ref>PMID:22825451</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Choi J]]
[[Category: Kim KK]]
[[Category: Kim T]]
[[Category: Lee S]]