View source for 5iy8


==Human holo-PIC in the initial transcribing state==
<SX load='5iy8' size='340' side='right' viewer='molstar' caption='[[5iy8]], [[Resolution|resolution]] 7.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iy8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IY8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iy8 OCA], [https://pdbe.org/5iy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iy8 RCSB], [https://www.ebi.ac.uk/pdbsum/5iy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iy8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPB7_HUMAN RPB7_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.<ref>PMID:9852112</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang J]]
[[Category: He Y]]
[[Category: Inouye C]]
[[Category: Ivanov I]]
[[Category: Nogales E]]
[[Category: Tjian R]]
[[Category: Yan C]]