View source for 5j0a


==Crystal structure of PDZ-binding kinase==
<StructureSection load='5j0a' size='340' side='right'caption='[[5j0a]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5j0a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J0A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j0a OCA], [https://pdbe.org/5j0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j0a RCSB], [https://www.ebi.ac.uk/pdbsum/5j0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j0a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOPK_HUMAN TOPK_HUMAN] Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.<ref>PMID:10781613</ref> <ref>PMID:17482142</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Yang X]]
[[Category: Zhou H]]
[[Category: Zou QW]]