View source for 5jhg


==Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11==
<StructureSection load='5jhg' size='340' side='right'caption='[[5jhg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [https://pdbe.org/5jhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [https://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

==See Also==
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen Q]]
[[Category: Li J]]
[[Category: Miao L]]
[[Category: Wang F]]
[[Category: Wang R]]
[[Category: Yan Z]]
[[Category: Zhang H]]