View source for 5jjw


==Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain==
<StructureSection load='5jjw' size='340' side='right'caption='[[5jjw]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jjw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JJW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jjw OCA], [https://pdbe.org/5jjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jjw RCSB], [https://www.ebi.ac.uk/pdbsum/5jjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jjw ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:[https://omim.org/entry/175900 175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.<ref>PMID:15840095</ref> 
== Function ==
[https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.<ref>PMID:11959860</ref> 

==See Also==
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Tong Y]]
[[Category: Walker JR]]
[[Category: Zhang Q]]