View source for 5jkp


==Crystal structure of immunity protein Pa5087 from Pseudomonas aeruginosa==
<StructureSection load='5jkp' size='340' side='right'caption='[[5jkp]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JKP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.106&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jkp OCA], [https://pdbe.org/5jkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jkp RCSB], [https://www.ebi.ac.uk/pdbsum/5jkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jkp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9HU96_PSEAE Q9HU96_PSEAE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Pseudomonas aeruginosa PldB protein is a transkingdom effector secreted by the Type VI Secretion System (T6SS). PA5088, PA5087, and PA5086 are three immunity proteins that can suppress the virulence of PldB. We report the crystal structures of PA5088 and PA5087 at 2.0 and 2.1 A resolution, respectively. PA5088 and PA5087 both consist of several Sel1-like Repeats (SLRs) and form super-ring folds. Our structural analysis of these proteins revealed key differences among PA5088, PA5087, and their homologs. Our docking experiments have shed light on the putative interaction mechanism of their function as phospholipase D inhibitors.

Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins.,Yang XY, Li ZQ, She Z, Geng Z, Xu JH, Gao ZQ, Dong YH FEBS Lett. 2016 Aug;590(16):2787-96. doi: 10.1002/1873-3468.12291. Epub 2016 Jul , 28. PMID:27397502<ref>PMID:27397502</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5jkp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Dong YH]]
[[Category: Gao ZQ]]
[[Category: Li ZQ]]
[[Category: She Z]]