View source for 5juw


==complex of Dot1l with SS148==
<StructureSection load='5juw' size='340' side='right'caption='[[5juw]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5juw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JUW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NR:(2~{S})-2-AZANYL-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-AZANYL-5-CYANO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLSULFANYL]BUTANOIC+ACID'>6NR</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5juw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juw OCA], [https://pdbe.org/5juw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5juw RCSB], [https://www.ebi.ac.uk/pdbsum/5juw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5juw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

==See Also==
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bayle ED]]
[[Category: Bountra C]]
[[Category: Brown PJ]]
[[Category: Edwards AM]]
[[Category: Fish PV]]
[[Category: Li Y]]
[[Category: Schapira M]]
[[Category: Spurr SS]]
[[Category: Tempel W]]
[[Category: Weigelt J]]
[[Category: Yu W]]