View source for 5jxc


==SynGAP Coiled-coil trimer==
<StructureSection load='5jxc' size='340' side='right'caption='[[5jxc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jxc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxc OCA], [https://pdbe.org/5jxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxc RCSB], [https://www.ebi.ac.uk/pdbsum/5jxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYGP1_MOUSE SYGP1_MOUSE] Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).

==See Also==
*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Shang Y]]
[[Category: Zhang M]]