View source for 5jxm


==Crystal Structure of Prenyltransferase PriB Apo Form==
<StructureSection load='5jxm' size='340' side='right'caption='[[5jxm]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._RM-5-8 Streptomyces sp. RM-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxm OCA], [https://pdbe.org/5jxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxm RCSB], [https://www.ebi.ac.uk/pdbsum/5jxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A182DWE5_9ACTN A0A182DWE5_9ACTN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207<ref>PMID:28166207</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5jxm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces sp. RM-5-8]]
[[Category: Benach J]]
[[Category: Cao H]]
[[Category: Elshahawi S]]
[[Category: Koss JW]]
[[Category: Morisco LL]]
[[Category: Phillips Jr GN]]
[[Category: Thorson JS]]
[[Category: Wasserman SR]]