View source for 5jyn


==Structure of the transmembrane domain of HIV-1 gp41 in bicelle==
<StructureSection load='5jyn' size='340' side='right'caption='[[5jyn]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jyn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYN FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyn OCA], [https://pdbe.org/5jyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyn RCSB], [https://www.ebi.ac.uk/pdbsum/5jyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q74849_9HIV1 Q74849_9HIV1] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) domain of HIV-1 Env reconstituted in bicelles that mimic a lipid bilayer. The TM forms a well-ordered trimer that protects a conserved membrane-embedded arginine. An amino-terminal coiled-coil and a carboxyl-terminal hydrophilic core stabilize the trimer. Individual mutations of conserved residues did not disrupt the TM trimer and minimally affected membrane fusion and infectivity. Major changes in the hydrophilic core, however, altered the antibody sensitivity of Env. These results show how a TM domain anchors, stabilizes, and modulates a viral envelope spike and suggest that its influence on Env conformation is an important consideration for HIV-1 immunogen design.

Structural basis for membrane anchoring of HIV-1 envelope spike.,Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ Science. 2016 Jul 8;353(6295):172-5. doi: 10.1126/science.aaf7066. Epub 2016 Jun , 23. PMID:27338706<ref>PMID:27338706</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5jyn" style="background-color:#fffaf0;"></div>

==See Also==
*[[Gp41 3D Structures|Gp41 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Chen B]]
[[Category: Chou JJ]]
[[Category: Dev J]]
[[Category: Fu Q]]
[[Category: Park D]]