View source for 5k5f


==NMR structure of the HLTF HIRAN domain==
<StructureSection load='5k5f' size='340' side='right'caption='[[5k5f]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5k5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2l1i 2l1i]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K5F FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k5f OCA], [https://pdbe.org/5k5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k5f RCSB], [https://www.ebi.ac.uk/pdbsum/5k5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k5f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bezsonova I]]
[[Category: Bountra C]]
[[Category: Dhe-Paganon S]]
[[Category: Edwards A]]
[[Category: Korzhnev D]]
[[Category: Neculai D]]
[[Category: Weigelt J]]