View source for 5kzd


==N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus with bound sialic acid alditol==
<StructureSection load='5kzd' size='340' side='right'caption='[[5kzd]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5kzd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_USA300 Staphylococcus aureus subsp. aureus USA300]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.334&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RCJ:(2~{S},4~{S},5~{R},6~{R},7~{S},8~{R})-5-ACETAMIDO-2,4,6,7,8,9-HEXAKIS(OXIDANYL)NONANOIC+ACID'>RCJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzd OCA], [https://pdbe.org/5kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kzd RCSB], [https://www.ebi.ac.uk/pdbsum/5kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANA_STAA8 NANA_STAA8] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).

==See Also==
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus USA300]]
[[Category: Dobson RCJ]]
[[Category: Fairbanks AJ]]
[[Category: Friemann R]]
[[Category: Muscroft-Taylor AC]]
[[Category: North RA]]
[[Category: Pearce FG]]
[[Category: Watson AJA]]