View source for 5lug


==Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide==
<StructureSection load='5lug' size='340' side='right'caption='[[5lug]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lug]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LUG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lug OCA], [https://pdbe.org/5lug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lug RCSB], [https://www.ebi.ac.uk/pdbsum/5lug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lug ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPI2B_HUMAN SPI2B_HUMAN] Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).<ref>PMID:12145692</ref> <ref>PMID:29061846</ref> 

==See Also==
*[[Spindlin|Spindlin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Edwards AM]]
[[Category: Gileadi C]]
[[Category: Huber K]]
[[Category: Kopec J]]
[[Category: Oppermann U]]
[[Category: Shrestha L]]
[[Category: Srikannathasan V]]
[[Category: Szykowska A]]
[[Category: Talon R]]
[[Category: Von Delft F]]