View source for 5lxo


==Coiled-coil protein==
<StructureSection load='5lxo' size='340' side='right'caption='[[5lxo]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lxo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.179&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxo OCA], [https://pdbe.org/5lxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxo RCSB], [https://www.ebi.ac.uk/pdbsum/5lxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN] Gliosarcoma;Giant cell glioblastoma. 
== Function ==
[https://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN] Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).[UniProtKB:Q9JJ11]<ref>PMID:14767476</ref> <ref>PMID:21297582</ref> <ref>PMID:23532825</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bunney TD]]
[[Category: Katan M]]
[[Category: Thiyagarajan N]]