View source for 5lxr


==Structure of the minimal RBM7 - ZCCHC8 Complex==
<StructureSection load='5lxr' size='340' side='right'caption='[[5lxr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxr OCA], [https://pdbe.org/5lxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxr RCSB], [https://www.ebi.ac.uk/pdbsum/5lxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBM7_HUMAN RBM7_HUMAN] Possible involved in germ cell RNA processing and meiosis.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate how RBM7 is incorporated in the NEXT complex. We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 A resolution. On the basis of the structure, we identify a proline-rich segment within the splicing factor SAP145 with strong similarity to ZCCHC8. We show that this segment of SAP145 not only binds the RRM region of another splicing factor SAP49 but also the RRM of RBM7. These dual interactions of RBM7 with the exosome and the spliceosome suggest a model whereby NEXT might recruit the exosome to degrade intronic RNAs.

Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.,Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E Nat Commun. 2016 Dec 1;7:13573. doi: 10.1038/ncomms13573. PMID:27905398<ref>PMID:27905398</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5lxr" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Benda C]]
[[Category: Conti E]]
[[Category: Falk S]]
[[Category: Finogenova K]]