View source for 5lxu


==Structure of the DNA-binding domain of LUX ARRHYTHMO==
<StructureSection load='5lxu' size='340' side='right'caption='[[5lxu]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lxu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxu OCA], [https://pdbe.org/5lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxu RCSB], [https://www.ebi.ac.uk/pdbsum/5lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCL1_ARATH PCL1_ARATH] Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcriptional feedback circuit, by binding specific sites on PRR9 promoter. Binds to its own promoter, inducing a negative auto-regulatory feedback loop within the core clock. Binds to ELF3 and associates with ELF4 in a diurnal complex which is required for the expression of the growth-promoting transcription factors PIF4 and PIF5 and subsequent hypocotyl growth in the early evening.<ref>PMID:16006522</ref> <ref>PMID:16164597</ref> <ref>PMID:21236673</ref> <ref>PMID:21753751</ref> <ref>PMID:22311777</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Nanao MH]]
[[Category: Zubieta C]]