View source for 5m41


==Crystal structure of nigritoxine==
<StructureSection load='5m41' size='340' side='right'caption='[[5m41]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5m41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_nigripulchritudo Vibrio nigripulchritudo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M41 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m41 OCA], [https://pdbe.org/5m41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m41 RCSB], [https://www.ebi.ac.uk/pdbsum/5m41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m41 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Tetraconata (Pancrustacea) concept proposes that insects are more closely related to aquatic crustaceans than to terrestrial centipedes or millipedes. The question therefore arises whether insects have kept crustacean-specific genetic traits that could be targeted by specific toxins. Here we show that a toxin (nigritoxin), originally identified in a bacterial pathogen of shrimp, is lethal for organisms within the Tetraconata and non-toxic to other animals. X-ray crystallography reveals that nigritoxin possesses a new protein fold of the alpha/beta type. The nigritoxin N-terminal domain is essential for cellular translocation and likely encodes specificity for Tetraconata. Once internalized by eukaryotic cells, nigritoxin induces apoptotic cell death through structural features that are localized in the C-terminal domain of the protein. We propose that nigritoxin will be an effective means to identify a Tetraconata evolutionarily conserved pathway and speculate that nigritoxin holds promise as an insecticidal protein.

Nigritoxin is a bacterial toxin for crustaceans and insects.,Labreuche Y, Chenivesse S, Jeudy A, Le Panse S, Boulo V, Ansquer D, Pages S, Givaudan A, Czjzek M, Le Roux F Nat Commun. 2017 Nov 1;8(1):1248. doi: 10.1038/s41467-017-01445-z. PMID:29093459<ref>PMID:29093459</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5m41" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio nigripulchritudo]]
[[Category: Czjzek M]]
[[Category: Jeudy A]]
[[Category: Labreuche L]]
[[Category: Le Roux F]]