View source for 5mea


==Crystal structure of yeast Cdt1 (N terminal and middle domain), form 2.==
<StructureSection load='5mea' size='340' side='right'caption='[[5mea]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MEA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.152&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mea OCA], [https://pdbe.org/5mea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mea RCSB], [https://www.ebi.ac.uk/pdbsum/5mea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mea ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDT1_YEAST CDT1_YEAST] DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins.<ref>PMID:11560884</ref> <ref>PMID:11967159</ref> <ref>PMID:16387651</ref> <ref>PMID:16824194</ref> <ref>PMID:17825064</ref> <ref>PMID:18006685</ref> <ref>PMID:19896182</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Cherepanov P]]
[[Category: Diffley JFX]]
[[Category: Frigola J]]
[[Category: Pye VE]]