View source for 5mh5


==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 A resolution)==
<StructureSection load='5mh5' size='340' side='right'caption='[[5mh5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mh5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloferax_mediterranei_ATCC_33500 Haloferax mediterranei ATCC 33500]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MH5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7N5:2-oxidanylidenehexanoic+acid'>7N5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mh5 OCA], [https://pdbe.org/5mh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mh5 RCSB], [https://www.ebi.ac.uk/pdbsum/5mh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mh5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Haloferax mediterranei ATCC 33500]]
[[Category: Large Structures]]
[[Category: Baker PJ]]
[[Category: Bisson C]]
[[Category: Domenech Perez J]]
[[Category: Ferrer J]]
[[Category: Harding SE]]
[[Category: Pramanpol N]]
[[Category: Rice DW]]