View source for 5mhj


==ICP4 DNA-binding domain, lacking intrinsically disordered region, in complex with 12mer DNA duplex from its own promoter==
<StructureSection load='5mhj' size='340' side='right'caption='[[5mhj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mhj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.117&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhj OCA], [https://pdbe.org/5mhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mhj RCSB], [https://www.ebi.ac.uk/pdbsum/5mhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICP4_HHV11 ICP4_HHV11] Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.<ref>PMID:18094162</ref> <ref>PMID:18216093</ref> <ref>PMID:1846804</ref> <ref>PMID:22496239</ref> <ref>PMID:23135715</ref> <ref>PMID:24147125</ref> <ref>PMID:8649420</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human alphaherpesvirus 1]]
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Baldock C]]
[[Category: Golovanov AP]]
[[Category: Jowitt TA]]
[[Category: Levy C]]
[[Category: Lockhart-Cairns MP]]
[[Category: Mould P]]
[[Category: Sandri-Goldin RM]]
[[Category: Sito H]]
[[Category: Tunnicliffe RB]]