View source for 5mmu


==NMR solution structure of the major apple allergen Mal d 1==
<StructureSection load='5mmu' size='340' side='right'caption='[[5mmu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Malus_domestica Malus domestica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmu OCA], [https://pdbe.org/5mmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmu RCSB], [https://www.ebi.ac.uk/pdbsum/5mmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAL11_MALDO MAL11_MALDO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
More than 70% of birch pollen-allergic patients develop allergic cross-reactions to the major allergen found in apple fruits (Malus domestica), the 17.5 kDa protein Mal d 1. Allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1. Immunologic cross-reactivity of Bet v 1-specific IgE antibodies with Mal d 1 after apple consumption can subsequently provoke severe oral allergic syndromes. This study presents the three-dimensional NMR solution structure of Mal d 1 (isoform Mal d 1.0101, initially cloned from 'Granny Smith' apples). This protein is composed of a seven-stranded antiparallel beta-sheet and three alpha-helices that form a large internal cavity, similar to Bet v 1 and other cross-reactive food allergens. The Mal d 1 structure provides the basis for elucidating the details of allergic cross-reactivity between birch pollen and apple allergens on a molecular level.

Structure of the Major Apple Allergen Mal d 1.,Ahammer L, Grutsch S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2017 Mar 1;65(8):1606-1612. doi: 10.1021/acs.jafc.6b05752., Epub 2017 Feb 15. PMID:28161953<ref>PMID:28161953</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Malus domestica]]
[[Category: Ahammer L]]
[[Category: Grutsch S]]
[[Category: Kamenik AS]]
[[Category: Liedl KR]]
[[Category: Tollinger M]]